diff --git a/docs/project/changelog.md b/docs/project/changelog.md
index 68b4ccedc66..6774939defc 100644
--- a/docs/project/changelog.md
+++ b/docs/project/changelog.md
@@ -118,6 +118,7 @@ myst:
 - Upgraded `tree-sitter-python` to 0.23.4 {pr}`5185`
 - Upgraded `lakers-python` to 0.4.1 {pr}`5225`
 - Upgraded `pure-eval` to 0.2.3 {pr}`5086`, {pr}`5244`
+- Upgraded `cffi` to 1.17.1 {pr}`5261`
 
 ## Version 0.26.4
 
diff --git a/packages/cffi/meta.yaml b/packages/cffi/meta.yaml
index a3b87ad68be..5f58139583e 100644
--- a/packages/cffi/meta.yaml
+++ b/packages/cffi/meta.yaml
@@ -1,16 +1,14 @@
 package:
   name: cffi
-  version: 1.16.0
+  version: 1.17.1
   top-level:
     - cffi
 requirements:
   run:
     - pycparser
 source:
-  url: https://files.pythonhosted.org/packages/68/ce/95b0bae7968c65473e1298efb042e10cafc7bafc14d9e4f154008241c91d/cffi-1.16.0.tar.gz
-  sha256: bcb3ef43e58665bbda2fb198698fcae6776483e0c4a631aa5647806c25e02cc0
-  patches:
-    - patches/0001-Use-libffi-in-emscripten.patch
+  url: https://files.pythonhosted.org/packages/fc/97/c783634659c2920c3fc70419e3af40972dbaf758daa229a7d6ea6135c90d/cffi-1.17.1.tar.gz
+  sha256: 1c39c6016c32bc48dd54561950ebd6836e1670f2ae46128f67cf49e789c52824
 build:
   cross-build-env: true
 about:
diff --git a/packages/cffi/patches/0001-Use-libffi-in-emscripten.patch b/packages/cffi/patches/0001-Use-libffi-in-emscripten.patch
deleted file mode 100644
index bc8605fd485..00000000000
--- a/packages/cffi/patches/0001-Use-libffi-in-emscripten.patch
+++ /dev/null
@@ -1,35 +0,0 @@
-From d23eff39a97bc172e6c175d944553411a1514c56 Mon Sep 17 00:00:00 2001
-From: Hood Chatham <roberthoodchatham@gmail.com>
-Date: Mon, 29 Jan 2024 15:35:52 -0800
-Subject: [PATCH] Use libffi in emscripten
-
-Upstreamed:
-https://github.com/python-cffi/cffi/pull/53
-
----
- src/c/_cffi_backend.c | 9 +++++++++
- 1 file changed, 9 insertions(+)
-
-diff --git a/src/c/_cffi_backend.c b/src/c/_cffi_backend.c
-index 537271fb..93c9cb29 100644
---- a/src/c/_cffi_backend.c
-+++ b/src/c/_cffi_backend.c
-@@ -112,6 +112,15 @@
- # define CFFI_CHECK_FFI_PREP_CIF_VAR __builtin_available(macos 10.15, ios 13, watchos 6, tvos 13, *)
- # define CFFI_CHECK_FFI_PREP_CIF_VAR_MAYBE 1
- 
-+#elif defined(__EMSCRIPTEN__)
-+
-+# define CFFI_CHECK_FFI_CLOSURE_ALLOC 1
-+# define CFFI_CHECK_FFI_CLOSURE_ALLOC_MAYBE 1
-+# define CFFI_CHECK_FFI_PREP_CLOSURE_LOC 1
-+# define CFFI_CHECK_FFI_PREP_CLOSURE_LOC_MAYBE 1
-+# define CFFI_CHECK_FFI_PREP_CIF_VAR 1
-+# define CFFI_CHECK_FFI_PREP_CIF_VAR_MAYBE 1
-+
- #else
- 
- # define CFFI_CHECK_FFI_CLOSURE_ALLOC 0
--- 
-2.25.1
-